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T61562 |
CB1R Allosteric modulator 3
|
|
cAMP
,
Cannabinoid Receptor
|
|
CB1R Allosteric modulator 3 is a potent CB1R modulator.CB1R Allosteric modulator 3 inhibits cAMP and β-Arrestin, and can be used for the study of obesity and nicotine addiction. |
|
T4573 |
Cyclothiazide
|
|
GluR
|
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Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M). |
|
T21747 |
VU0483605
|
|
GluR
|
|
VU0483605 is an effective and selective positive allosteric modulator of mGluR1 with EC50s of 390 and 356 nM for human and rat, respectively. |
|
T22711 |
DCB
|
3,3'-dichlorobenzaldazine |
Others
,
GluR
|
|
DCB (3,3'-dichlorobenzaldazine) is an allosteric ligand for mGluR5 and shows the negative modulatory effect of 3,3′-dimethoxybenzaldazine (DMeOB). DCB blocks the positive allosteric regulation of mGluRs with the help of ... |
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T26869 |
BMS-986122
|
BMS 986122 |
Opioid Receptor
|
|
BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5... |
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T62016 |
CB1R Allosteric modulator 1
|
|
|
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CB1R Allosteric modulator 1 (compound 11) is a potent allosteric modulator of CB1R. CB1R Allosteric modulator 1 negatively affects the functional activity of orthosteric ligands (NAM) at CB1Rs. |
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T9699 |
TAK-615
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LPA Receptor
|
|
TAK-615 is commonly used to study pulmonary fibrosis and is a negative allosteric modulator of LPA1 receptors. |
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T61276 |
CB1R Allosteric modulator 2
|
|
|
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CB1R Allosteric modulator 2 (compound 18) is a potent allosteric modulator of the CB1R receptor. It exhibits negative modulation of the functional activity of orthosteric ligands (NAM) at CB1Rs, as demonstrated in previo... |
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T61371 |
CB1R Allosteric modulator 4
|
|
|
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CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arresti... |
|
T28069 |
ML380
|
ML 380,ML-380 |
AChR
|
|
ML380 is a highly potent and the first CNS penetrant M5 positive allosteric modulator (PAM). |
|
T29137 |
VU0453595
|
VU 0453595,VU-0453595 |
AChR
|
|
VU0453595 is a M1 positive allosteric modulator (PAM). |
|
T8776 |
FEMA 4774
|
S9632 |
Others
|
|
FEMA 4774 (S9632) is a positive allosteric modulator of T1R2/T1R3. FEMA4774 shows obvious enhancement of the sweetness of sucrose in sensory evaluation tests |
|
T23469 |
TQS
|
4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide |
AChR
|
|
TQS (4-Naphthalen-1-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline-8-sulfonamide) is a positive allosteric modulator of α7 nACh receptors. |
|
T23524 |
W-84 dibromide
|
HDMPPA |
AChR
|
|
W-84 dibromide (HDMPPA) is a M2-receptor selective modulator. |
|
T7165 |
Basmisanil
|
RG1662,RO5186582 |
GABA Receptor
|
|
Basmisanil (RG1662) is a negative allosteric modulator/inverse agonist of GABAAα5 receptors.Formulations containing basmisanil are in clinical trials for the treatment of cognitive impairments associated with Down syndro... |
|
T1884 |
CX516
|
Ampakine CX516,BDP 12,Ampalex |
GluR
,
iGluR
|
|
CX516 (Ampalex), an ampakine and nootropic, acts as an AMPA receptor positive allosteric modulator as a therapy for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). |
|
T60047 |
V-0219
|
|
Glucagon Receptor
|
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V-0219 is a positive allosteric modulator of GLP-1 and can be used in studies about obesity-associated diabetes. |
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T4522 |
SSD114 HCl
|
|
GABA Receptor
|
|
SSD114 is a novel GABAB receptor positive allosteric modulator. |
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T22976 |
MFZ 10-7
|
|
Others
,
GluR
|
|
MFZ 10-7 is anegative allosteric modulator of the mGluR5. |
|
T15942 |
MK-7622
|
M1 receptor modulator |
AChR
|
|
MK-7622 (M1 receptor modulator) is a modulator of muscarinic M1 receptor positive allosteric. |
|
T23481 |
U 89843A
|
|
GABA Receptor
|
|
Positive allosteric modulator of GABAA receptors |
|
T10573 |
BMT-145027
|
|
GluR
|
|
BMT-145027 is a positive allosteric modulator of mGluR5 without inherent agonist activity (EC50 = 47 nM). |
|
T11458 |
GPR40/FFAR1 modulator 1
|
|
GPR
|
|
GPR40/FFAR1 modulator 1 is a Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1) agonist and allosteric modulator. |
|
T29126 |
VU0360172
|
VU-0360172,VU 0360172 |
GluR
|
|
VU0360172 is a positive allosteric modulator of mGlu5 receptors (EC50 = 16 nM; Ki = 195 nM). |
|
T26719 |
AZD6538
|
AZD 6538,AZD-6538 |
GluR
|
|
AZD6538 is an mGluR5 negative allosteric modulator used in the study of CNS-related diseases such as Alzheimer's disease. |
|
T27679 |
JNJ-39393406
|
|
AChR
|
|
JNJ-39393406 is an α7 nicotinic acetylcholine receptor positive allosteric modulator for the study of tobacco dependence and Alzheimer's disease. |
|
T23003 |
ML337
|
ML 337 |
GluR
|
|
ML337 is a negative allosteric modulator of mGlu3 with an IC50 of 593 nM. |
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T16402 |
Org-26576
|
|
GluR
,
iGluR
|
|
Org-26576 is a positive allosteric modulator of the AMPA receptor. |
|
T9970 |
MGluR3 modulator-1
|
1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile |
GluR
|
|
mGluR3 modulator-1 (1-ethyl-3-(morpholin-4-yl)-5,6,7,8-tetrahydroisoquinoline-4-carbonitrile) is a positive allosteric modulator of mGluR3 and can be used in studies about the treatment of Parkinson's disease. |
|
T17300 |
(-)-(S)-B-973B
|
|
AChR
|
|
(-)-(S)-B-973B is an effective allosteric agonist and a positive allosteric modulator of α7 nAChR. |
|
T7805 |
GW791343 dihydrochloride
|
GW791343 (HCl) |
P2X Receptor
|
|
GW791343 dihydrochloride (GW791343 (HCl)) is a P2X7 allosteric modulator. |
|
T7292 |
FITM
|
|
GluR
|
|
FITM is a potent negative allosteric modulator of mGlu1 receptor(Ki : 2.5 nM). |
|
T6160 |
VU 0364439
|
|
GluR
|
|
VU 0364439 is a mGlu4 positive allosteric modulator (C50: 19.8 nM). |
|
TQ0040 |
ONO-8590580
|
CS-2894 |
GABA Receptor
|
|
ONO-8590580 (CS-2894) is a negative allosteric modulator of GABAA α5. |
|
T29112 |
VPC171
|
VPC 171,VPC-171 |
Adenosine Receptor
|
|
VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM). |
|
T3565 |
VU0155041
|
UV0155041,VU-0155041 |
GluR
|
|
VU0155041 is an effective and positive allosteric modulator/allosteric agonist at mGlu4 receptors (EC50: 798/693 nM, at human/rat). |
|
T3993 |
BQCA
|
benzylquinolone carboxylic acid |
AChR
|
|
BQCA (benzylquinolone carboxylic acid) a highly selective allosteric M1 mAChR modulator. |
|
T27951 |
LY392098
|
LY-392098,LY 392098,AMPA receptor modulator-3 |
GluR
,
iGluR
|
|
LY392098 (AMPA receptor modulator-3) is an allosteric modulator of AMPA receptor with EC50 of 4.4 μM and can be used in studies about mammalian nervous system. |
|
T23514 |
VU-1545
|
VU 1545 |
GluR
|
|
VU-1545 is mGlu5 positive allosteric modulator. |
|
T19698 |
CX614
|
CX 614,CX-614 |
GluR
|
|
CX614 is a positive allosteric modulator of the AMPA receptor with respect to AMPA. |
|
T10432L |
AZD-8529 mesylate
|
|
GluR
|
|
AZD-8529 mesylate is a highly selective, and orally bioavailable positive allosteric modulator of mGluR2 (EC50: 285 nM). It shows no positive allosteric modulator responses at 20-25 M on the mGluR1, 3, 4, 5, 6, 7, and 8 ... |
|
T15619 |
JNJ-46778212
|
VU 0409551 |
GluR
|
|
JNJ-46778212 (VU 0409551) is a selective and potent mGlu5 allosteric modulator (EC50: 260 nM) for the study of neurodissection. |
|
T9238 |
KI-7
|
|
Adenosine Receptor
|
|
KI-7 is an adenosine A2B receptor positive allosteric modulator. |
|
T29118 |
VU 0469650
|
VU0469650,VU 0469650,VU-0469650,VU 0469650 HCl |
GluR
|
|
VU 0469650 is a potent and selective negative allosteric modulator of mGluR1 (IC50 = 99 nM). |
|
T3451 |
JNJ-42153605
|
|
GluR
|
|
JNJ-42153605 is a mGlu2 receptor positive allosteric modulator (EC50: 17 nM). |
|
T16860 |
SBI-553
|
|
Neurotensin Receptor
|
|
SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM). |
|
T5375 |
Loreclezole
|
|
GABA Receptor
|
|
Loreclezole is a selective GABAA receptor modulator and acts as a positive allosteric modulator of β2 or β3-subunit-containing receptors. |
|
T14571 |
Bifenazate
|
|
GABA Receptor
|
|
Bifenazate is a carbazate acaricide that control 100% of mites at a concentration of 25 ppm[1] and it also is a positive allosteric modulator of GABA receptor[2]. |
|
T22813 |
GS 39783
|
|
GABA Receptor
|
|
GS 39783 is a positive allosteric modulator (PAM) of GABABR, which reduces the motivational properties of alcohol and the conditioned reinforcement and conditional reward of psychostimulants. |
|
T13441 |
(R)-ADX-47273
|
|
GluR
|
|
(R)-ADX-47273 is a potent mGluR5 positive allosteric modulator(EC50 of 168 nM for potentiation ). |
